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University of Rochester Sr Bioinformatics Analyst, Genomics Research Ctr - 232064 in Rochester, New York

Sr Bioinformatics Analyst, Genomics Research Ctr Job ID 232064

Location School of Medicine & Dentistry Full/Part Time Full-Time Favorite Job Regular/Temporary Regular Opening

Full Time 40 hours Grade 054 Ctr for Advanced Research Tech

Schedule

8 AM-5 PM

Responsibilities

POSITION SUMMARY:

The Genomics Research Center (GRC) and The Center for Musculoskeletal Research (CMSR) at The University of Rochester are seeking a highly trained, motivated, and passionate Bioinformatics Analyst to join a collaborative Bioinformatics group providing applied bioinformatics analytical support to research scientists utilizing high-throughput sequencing and other data types for their research. The ideal candidate should have a solid foundation in molecular biology, genomics, and bioinformatics as well as be able to communicate and work with a diverse research team. Specifically, the applicant will work under direct supervision of the Director of the GRC to quality control raw data, identify dysregulated gene and pathways, integrate disparate datasets into regulatory frameworks. A signinificant focus will be on single-cell and spatial -omic analysis. The successful applicant will work with faculty members in the CMSR and URMC with a wide range of expertise including bone, cartilage, tendon, cancer, stem cell biology, etc. The GRC Bioinformatics Group routinely performs analysis of data including, but not limited to mRNA-seq (bulk and single-cell), micro RNA-seq, total RNA-seq, ChIP-seq, ATAC-seq, whole genome and exome sequencing, methylation sequencing, and micro array using cutting edge analytical methods as well as educates the research community on best practices for informatics. The GRC provides a highly interactive environment with collaborative opportunities across basic and clinical departments, access to high performance computing clusters, highly automated analytical pipelines and integration with high-throughput sequencing infrastructure to aid in experimental design and execution for delivery of high-quality results for highly competitive projects. This position is located in Rochester, NY and located within the Wilmot Cancer Institute. This position will report directly to the Director of the Genomics Research Center (GRC) and will operate with minimal supervision.

TYPICAL DUTIES:

  • Analyze high-throughput sequencing data generated on high-throughput sequencing instruments. The sequence data will include: single-cell RNA-seq data from experimental approaches. This requires an extensive working knowledge of linux/unix commands, computer programming languages and application of open-source software tools . (20%)

  • Analyze high-throughput sequencing data generated on high-throughput sequencing instruments. The sequence data will include: spatial transciptomics data from experimental approaches. This requires an extensive working knowledge of linux/unix commands, computer programming languages and application of open-source software tools . (20%)

  • Participate in experimental design and analysis of sequencing projects. This includes application and development of novel analytical methods to meet each projects research goals, management of project milestones, and integration of multiple genomic data types . (20%)

  • Secondary analyses of processed data including expression profiling, pathway enrichment analysis, functional annotation, transcription factor binding site prediction, putative motif identification, and chromatin accessibility prediction. (20%)

  • Analyze high-throughput sequencing data generated on high-throughput sequencing instruments. The sequence data will include: transcriptome sequence data from experimental approaches such as bulk RNA-seq. This requires an extensive working knowledge of linux/unix commands, computer programming languages and application of open-source software tools . (10%)

  • Provide bioinformatics support and training to research groups, including use of various software for analysis of genomic data, assistance in analysis and interpretation of data sets, and recommendation of best practices for sequencing experiments . (5%)

  • Storage and maintenance (data management) of raw data including but not limited to micro array and high-throughput sequence data sets . (5%)

Other projects and job duties as assigned.

Desired Skills and Experience :

  • Advanced degree (MS or higher) with background in bioinformatics, computational biology, or a related field preferred. Minimum requirements include a bachelor's degree in related discipline such as Computer Science, Business, Mathematics, Statistics, Science or Engineering; and 3-4 years of related experience, preferably 1-2 years in a supervisory capacity; or an equivalent combination of education and experience.

  • Experience with statistical programming and data visualization using R/Bioconductor and UNIX/Linux programming required.

  • Competency with Python, JAVA, Perl, C++, and Cloud computing strongly preferred.

  • Strong knowledge of basic statistics, linear model building, principal component analysis, and factor analysis required.

  • Excellent interpersonal, presentation and communication skills, including written communication.

  • Strong organizational and analytical skills; and the ability to work in a highly cooperative team environment as well as independently.

    NOTE: This document describes typical duties and responsibilities and is not intended to limit management from assigning other work as required.

    How To Apply

All applicants must apply online.

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