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University of Rochester Medical Technologist ¿ Spec (Histocompatibility Technologist) - 233379 in Rochester, New York

Medical Technologist ¿ Spec (Histocompatibility Technologist) Job ID 233379

Location Strong Memorial Hospital Full/Part Time Full-Time Favorite Job Regular/Temporary Regular Opening

Full Time 40 hours Grade 097 Tissue Typing - Clin Labs SMH


Position Summary:

Performs complete histocompatibility evaluations on organ, tissue and BM recipients and donors as well as patients with specific HLA-associated conditions. Testing is routinely performed without supervision, complex interpretation of results is required. Candidates must demonstrate proficiency at all aspects of test principles and methodologies and be able to make judgments about applications for specific cases.


BS degree in Biology, Medical Technology, or related science with 1-2 years clinical laboratory experience. Must hold current NYS technologist licensure. Strong candidate will have previous experience in field of Histocompatibility.

Supervision and Direction Exercised:

May perform as supervising technologist for new employees and students. Coordinates training of fellows and medical students. Complex decision making without supervision is routine.

Machines and Equipment Used:

Centrifuges, fluorescent microscope, flow cytometer, thermal cycler, gel electropheresis apparatus, Luminex Instrument, RT PCR, Next Generation Sequencing instrument, computer (transplant database and other software) and other automated support equipment.

Histocompatiblity Testing – 75%

  • Isolates lymphocytes from peripheral blood, lymph nodes and spleen, and monitors purity and viability with microscope. Isolates subsets of lymphocyte population using multiple techniques for use in testing.

  • Performs HLA typing for Class I and II antigens by:

  • Serologic microlymphocytoxicity using cell populations isolated above. Selects appropriate reagents based on patient type. Plates cells on trays, reads trays by fluorescence microscopy, analyzes and interprets results.

  • DNA methods: Isolates and quantitates DNA from tissues as above and prepares testing by polymerase chain reaction. Performs typing by using sequence specific primers and by oligonucleotide probe detection. Runs Electrophoretic gels, analyzes and interprets results.

  • May report results to physicians or coordinator without supervisor review.

  • Performs antibody detection and crossmatching.

  • Crossmatching is performed by serological technique and by flow cytometry. Selects appropriate patient and sera to test based on patient history. Sets up cytometer and runs assay.

  • Antibody screening is performed by serology and Luminex methods. Makes decisions for appropriate testing based on patient history and current laboratory algorithm.

  • May perform cell tissue culture techniques using aseptic procedures as needed.

  • Participates in 24-hour on call rotation. Proficient at all testing above, and able to run all tests on a specific patient simultaneously. Performs complete deceased organ donor work-up without supervision. Analyzes and interprets results of tests, provides data to the United Network for Organ Sharing. Uses feedback from UNOS for determining local organ allocation. Responsible for determining compatibility between potential donors and recipients.

  • Communicates effectively and appropriately the test results and interpretations to transplant physicians and transplant coordinators. Coordinates provision of sharing materials with FLDRN staff.

  • Performs testing and prepares initial analysis of data in the development of new clinical assays.

  • Reviews and revises procedure manuals at least biannually. Writes procedures for new applications.

  • Trains new employees in performance of tests outlined above. Provides feedback to supervisor and director regarding performance of test materials.

  • Promotes team work with fellow employees for the efficient, effective and successful running of the tissue typing laboratory.

Regulatory/Quality Assurance Duties – 25%

  • Participates in quality control and housekeeping of laboratory and proficiency testing programs. Assists in developing QI initiatives by monitoring activities and suggesting changes.

  • Maintains written and computer records of patient test, QA, and equipment QC results.

  • Participates in lab in-service education programs, provides in-service training for allied personnel.

  • Provides technical training for post-doctoral fellows/graduate students in histocompatiblity testing.

    How To Apply

All applicants must apply online.

EOE Minorities/Females/Protected Veterans/Disabled